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Mar 29, - Mitochondria what's that? Mitochondrial disease in adults is a complicated disorder to diagnose. It has myriad signs and symptoms and body. Jul 6, - The main symptoms of mitochondrial myopathy are muscle fatigue, weakness, and exercise intolerance. People with mitochondrial myopathies also may experience muscle weakness in their arms and legs.‎What are the symptoms of · ‎Are there specific · ‎How are mitochondrial.